Pii: S0955-0674(00)00194-0
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چکیده
Hypoxia-inducible factor 1 (HIF-1) is an oxygen-regulated transcriptional activator that plays essential roles in mammalian development, physiology and disease pathogenesis. The HIF-1α subunit is subjected to oxygen-dependent ubiquitination and proteasomal degradation that is mediated by the von Hippel-Lindau protein. Interaction of HIF-1α transactivation domains with coactivators is induced by hypoxia. The signal transduction pathway remains enigmatic, but involves generation of reactive oxygen species. Nitric oxide induces HIF-1α under non-hypoxic conditions but inhibits hypoxia-induced HIF-1α expression.
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Pii: S0955-0674(00)00237-4
Nerve terminals are highly enriched in proteins needed for endocytosis. Although constitutive and ligand-stimulated endocytosis take place in nerve terminals, the primary type is compensatory endocytosis — the process by which a cell retrieves the additional membrane added to cell surface by a regulated secretory event. This process has been extensively characterized using electrophysiological ...
متن کاملPii: S0955-7997(99)00050-8
Fundamental solutions to a generalized Helmholtz equation are determined through dependent variable transforms using the material properties and independent variable transforms based on conformal mapping. This allows variable wave speed media to be examined under some fairly broad material property constraints. q 2000 Elsevier Science Ltd. All rights reserved.
متن کاملPii: S0041-0101(00)00194-x
The present report describes the use of ELISA with cDNA expression libraries in the identification of immunogenic proteins. The methodology described was applied using libraries constructed with mRNA isolated from Tityus serrulatus and Tityus bahiensis venom glands. In addition we describe for the first time the sequence of a neurotoxin from Tityus bahiensis venom gland named TbTx5 whose amino ...
متن کاملPii: S0140-3664(00)00194-8
Ef®cient resource utilisation in future cellular systems is related to the control of the signalling load imposed by the location update and paging operations. Important means for controlling this load is the apropero planning of location areas. In this paper we de®ne and solve a version of the location area planning problem. Starting from a formal de®nition and an optimal formulation of the pr...
متن کاملFinitary PCF is not decidable
The question of the decidability of the observational ordering of finitary PCF was raised [5] to give mathematical content to the full abstraction problem for PCF [9, 14]. We show that the ordering is in fact undecidable. This result places limits on how explicit a representation of the fully abstract model can be. It also gives a slight strengthening of the author’s earlier result on typed λ-d...
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تاریخ انتشار 2001